She is arguably the longest-serving combat front-line submarine still existing in the world, having been commissioned by two different countries for 56 years of active duty.

Her first war patrol, commencing 25 August, was conducted east of Luzon as a member of an offensive group in support of the mid-September Palau landings.

On 15 November Razorback sailed from Midway Island on her second war patrol in company with Trepang and Segundo.

After sinking four wooden ships in three separate surface gun actions, she deposited three Japanese prisoners at Guam before terminating her patrol at Pearl Harbor on 26 March 1945.

On 22 July Razorback departed Midway Island for patrol in the Okhotsk Sea, where she sank six wooden cargo sea trucks (i.e., small Imperial Japanese Navy ship types used for frontline logistics) and damaged two in a surface gun action.

On 31 August Razorback entered Tokyo Bay with 11 other submarines to take part in the formal Japanese surrender.

An ASROC with a 10-kiloton, W44 nuclear depth charge warhead was fired by the destroyer Agerholm at a target raft from a range of 2 nautical miles (3.7 km).

Razorback was submerged at periscope depth approximately 2 miles (3.2 km)[clarification needed] from the target raft.

The submarine was recommissioned TCG Muratreis (S-336) on 17 December 1971, named after the great Ottoman admiral Murat Reis and served Turkey for 31 years, decommissioning on 8 August 2001.

After a stopover for the dedication of the Montgomery Point Lock and Dam on 16 July, her transit was delayed by the United States Army Corps of Engineers over safety concerns.

On 29 August 2004, Razorback reached her berth in North Little Rock, at the Arkansas Inland Maritime Museum.

Razorback was also the meeting place the Quapaw Area Council Sea Scout ship number 394.

Visitors to the Arkansas Inland Maritime Museum can tour the submarine most Fridays, Saturdays, and Sundays.

[20] The USS Razorback is featured in the fictional book SSN Seadragon The Crucible of Leviathan by J.P. Ronald.