The first USS Rehoboth (SP-384) was a United States Navy patrol vessel in commission in 1917.

The U.S. Navy acquired her from W. C. Lofland of Lewes, Delaware, for service during World War I, armed her, designated her SP-384, and commissioned her at Philadelphia, Pennsylvania on 12 May 1917.

Acquired originally for section patrol duty, Rehoboth was designated for distant service in June 1917, and on 14 August 1917 headed for Boston, Massachusetts.

Steaming via the Azores, she reached Brest, France on 18 September 1917 and began operations as a unit of Division 12, Patrol Force.

Her crew — unable to control the flooding — was taken off, and she was sunk by the British light cruiser HMS Castor.