USS San Francisco (SSN-810) will be a Virginia-class nuclear-powered attack submarine of the United States Navy, the ninth of the Block V boats and the 37th overall of her class.

She will be the fourth US naval vessel named for San Francisco, California, one of the most densely populated cities in the U.S.

The third, (SSN-711), also an attack submarine, is a Los Angeles-class boat that after decommissioning, became a moored training ship for the Nuclear Power School in South Carolina.

The submarine's name was announced on 3 October 2023 by Navy Secretary Carlos Del Toro while attending Fleet Week in San Francisco.

The VPM inserts a segment into the boat's hull which adds four vertical launch tubes.