As an MSC vessel, San Jose was involved in the INTERFET peacekeeping taskforce, the response to the December 2004 Indian Ocean tsunami, as well as the wars in Afghanistan and Iraq.

Arriving on 10 February, she took on her first PACFILL (Pacific Fleet Issue Load List) stock, and, in March, completed final contract trials.

The stores ship arrived at Subic Bay, Philippines, on 27 September; topped off her load; and, on 4 October, departed for the Tonkin Gulf and her first line swing.

From the Tonkin Gulf, San Jose delivered freight at Danang, Cam Ranh Bay, and Vũng Tàu; then conducted underway replenishments off the southern coast of South Vietnam before moving on to a port visit at Singapore, whence she headed back to the Philippines to take on more cargo.

San Jose resumed local operations out of Oakland and NAS Alameda, California, until redeploying to the U.S. 7th Fleet on 26 August 1972.

She arrived in Subic Bay on 12 September and, after nine months supporting the 7th Fleet in the Far East, departed Sasebo, Japan, on 11 June 1973 to return to the United States.