The hospital ship was in constant service during the Spanish–American War, returning wounded and ill servicemen from Cuba to Norfolk, New York, and Boston.

She returned to sea on 1 July 1899 and, until October 1905, carried mail, passengers, and provisions from San Francisco to Hawaii, Guam, the Philippine Islands, China, and Japan.

Recommissioned again on 20 November 1909, Solace joined the Atlantic Fleet on 6 December 1909 and served as a hospital ship at ports along the eastern seaboard of the United States from Newport, Rhode Island, to Key West, Florida.

On 1 January 1919, Solace was ordered to proceed to the vicinity of USS Northern Pacific, then aground off Fire Island, New York, loaded with wounded veterans returning from France.

She was decommissioned on 20 July 1921; struck from the Navy List on 6 August 1930; and sold to Boston Metals Co., Baltimore, Maryland, on 6 November for scrap.