USS Southampton (AKA-66) was a Tolland-class attack cargo ship in service with the United States Navy from 1944 to 1946.

She made Saipan on the 11th, conducted final invasion rehearsals off Tinian between the 13th and 15th, and got underway for Iwo Jima the following day.

She lowered landing craft and dispatched them to other ships of the division to ferry the assault troops to the beach.

Southampton sustained her only casualties of the Iwo Jima assault during the initial landings when a mortar shell exploded close aboard one of her LCVP's and wounded the coxswain and a seaman.

During the last two weeks in February, the attack cargo ship joined in unloading troops and supplies and embarking casualties from the fighting ashore.

On 1 April 1945, she and the other ships of her task group arrived off the southeastern coast of Okinawa to feign an attack and retire.

A Japanese plane flew over the formation and, though fired upon by all ships, escaped into the clouds apparently undamaged.

Southampton remained at Saipan until 4 June, when she was ordered to the South Pacific to pick up cargo for the Marianas.

En route, she was diverted to Tokyo Bay to avoid a typhoon and, on 3 October, her destination was changed to Manila where she arrived on the 14th.

Following a return voyage to Tokyo Bay and Yokohama, Southampton embarked 264 servicemen and got underway on 11 November for San Francisco, California.

Her name was struck from the Navy List on 3 July 1946 and sold into civilian service with American Export-Isbrandtsen Lines.