USS Spica (AK-16) was a Sirius-class cargo ship commissioned by the U.S. Navy for service in World War II.

Heading via Funafuti, she reached Kwajalein Atoll in January 1944 and returned, via Pearl Harbor, to Seattle, Washington, on 22 March.

Together they were delivering the Seabees of Construction Battalion Detachment 1058 and 8,200 long tons of supplies and equipment needed to explore Naval Petroleum Reserve #4.

Its name was struck from the Navy list on 7 February 1946, and it was delivered to the Maritime Commission for lay-up pending disposal.

Its crew members were eligible for the following medals: This article incorporates text from the public domain Dictionary of American Naval Fighting Ships.