[5][6] Spruance was the first of the U.S. Navy's destroyers to be fitted with the Gigabit Ethernet Data Multiplex System (GEDMS), manufactured by the Boeing Company.

[9] Spruance returned to Naval Base San Diego on 17 April 2014 following the completion of her maiden deployment to the Western Pacific Ocean.

[12] On 22 May 2022, Spruance steamed into Tokyo Bay as a part of Destroyer Squadron 2, along with USS Abraham Lincoln and Carrier Strike Group 3.

ODIN, a solid-state laser system, is designed primarily to counter and neutralize the sensors on UAS, effectively blinding them without destroying the aircraft.

Technical aspects of the ODIN system include its ability to emit a high-intensity laser beam, targeting the optical sensors of enemy drones.