Following firing exercises at the Atlantic Fleet weapons range and antisubmarine operations late in April, the destroyer escort participated in the search for missing nuclear submarine USS Scorpion (SSN-589) in May.

After overhaul at the Boston Naval Shipyard was completed on 1 April 1970, Talbot conducted local operations before returning to the missile range off Puerto Rico in May for weapons tests, followed by refresher training and four months at Newport.

Talbot made calls in Venezuela, Brazil, Uruguay, Argentina, Chile, Peru, the Panama Canal Zone, and Colombia before returning to Newport on 3 December 1972.

She stood out of Hampton Roads on 21 October and, from 12 November through 19 December 1974, tested the new systems at the Atlantic Fleet Weapons Range, Culebra, Puerto Rico.

While steaming in the Mediterranean, the Talbot experienced a ruptured fuel tank while refueling under-way and was forced to repair, In La Maddalena, Sardinia.The six-month operation included participation in NATO exercises interspersed with port visits and concluded with the ship's return to Norfolk on 10 January 1977.

Following post-deployment leave and upkeep, Talbot conducted exercises off the east coast until she entered the Philadelphia Naval Shipyard for overhaul on 9 June.

Completing overhaul on 7 April 1978, Talbot spent the balance of the year in refresher training and participating in Fleet exercises off the east coast and in the Caribbean.

On 6 December, she departed the United States for deployment with the Middle East Force in response to the crisis surrounding the deposition of the Shah of Iran.