[11] The design of Tripoli features an enlarged hangar deck, realignment and expansion of the aviation maintenance facilities, and a significant increase in her available stowage for parts and support equipment.

She was intended to be the first LHA replacement ship to deliver fully ready to integrate the entire future air combat element of the U.S. Marine Corps to include the F-35B Lightning II, but construction delays have pushed final F-35 capability installs until delivery.

[5] During the COVID-19 pandemic, on 17 April 2020, The Wall Street Journal reported that Navy officials had stated that at least 9 sailors assigned to the ship had tested positive for SARS-CoV-2.

[14] As a result of the pandemic, the ship's public commissioning ceremony originally planned to occur at NAS Pensacola in June was also cancelled.

[16] On 2 May 2022, Tripoli departed Naval Station San Diego for the Western Pacific Ocean on her maiden deployment, taking on 20 F-35Bs at one point in a test of the "lightning carrier" concept.

It was the decisive victory of a mercenary army led by a detachment of United States Marines and soldiers against the forces of Tripoli during the First Barbary War.