Steaming off the island's eastern shore, she screened cruiser Montpelier; joined briefly in the pre-assault bombardment and, late in the afternoon, engaged in a running battle with a coastal battery.

As darkness fell, she took up her station to screen vessels supplying night harassment fire at Garapan on Saipan's west coast.

[1] The next day, D-Day, she continued screening duties and fired on selected shore targets while marines landed on the western side of the island.

[1] Early on the morning of 17 June, Twining joined Destroyer Division 106 and steamed to rendezvous with Vice Admiral Willis A. Lee's battleships in anticipation of fleet action.

Throughout the battle, combat air patrol (CAP) planes disrupted the enemy onslaught, shooting down many Japanese aircraft and thwarting the approach of the rest.

Throughout the remainder of June, she continued to operate off Saipan, providing shore bombardment, night harassment, and illumination fire, as well as screening transports and engaging enemy aircraft.

Just before midnight on 30 June, as Twining patrolled off Nafutan Point, two enemy planes attempted to make runs on Aslito airfield but were turned back by heavy fire from the destroyer.

From there, the destroyer conducted antisubmarine patrols until the 30th when the task group got underway for the western Carolines and entered Ulithi lagoon on 6 October.

After Twining opened fire, the raider attempted to crash into her but rapidly lost altitude and splashed 300 yards off her port bow, spreading flaming gasoline over the water near the ship.

That day, as Twining continued her routine screening duties, planes from the carriers struck telling blows against Admiral Takeo Kurita's "Center Force" in the Sibuyan Sea.

Daylong strikes launched from the American flattops sank four enemy carriers of Admiral Jisaburo Ozawa's Northern Force in an action known as the Battle off Cape Engaño.

On 10 December, the destroyer got underway with Rear Admiral Montgomery's Fast Carrier Task Group to act as a picket during strikes on Luzon in support of the landings on Mindoro.

During a typhoon that battered the task force the next day, the weight of her full load of fuel gave Twining the added stability she needed to weather 65-foot seas and 50-degree rolls.

Ordered to stand by the disabled Monterey as the light carrier burned, dead in the water, Twining maintained a position near the stricken vessel throughout the storm.

[1] As dawn broke in moderating weather on 19 December, the destroyer accompanied the task force as it steamed on for a strike on Luzon; but, when bad weather aborted the strike, she returned to the scene of the typhoon to search for survivors from the three destroyers which had sunk during the storm, before returning to Ulithi on Christmas Eve to repair storm damage.

[1] Admiral William Halsey's 3rd Fleet departed on 30 December and set course for strikes on Formosa, the Ryukyus, and the China coast to prevent Japanese interference with the coming landings on Luzon at Lingayen Gulf.

After naval aircraft raided military targets in the Tokyo area on the 16th and 17th, the task group headed south toward the Volcano Islands.

The next day, Twining headed north in search of the Japanese fleet, then returned to Okinawan waters on the 31st, and resumed duty as a picket for carrier operations.

During a two-hour period, Twining's group splashed five kamikazes; but the destroyer was on the opposite side of the formation and had no opportunity for a clear shot.

A 380-plane strike located the Japanese ships in the East China Sea, near Amami Ōshima, and sank superbattleship Yamato, light cruiser Yahagi, and four destroyers.

Winds reached 70 knots (130 km/h) by 06:00, and Twining again faced the might of a typhoon but emerged undamaged and resumed her picket duties late in the day.

[1] After upkeep and availability in San Pedro Bay, she screened Yorktown in Leyte Gulf as the carrier exercised a newly assigned air group.

At 06:05 on 15 August, Twining heard the carriers recall strikes bound for Tokyo targets; and, two hours later, Radio San Francisco announced the welcome news of Japan's unconditional capitulation.

[1] Late in August, Twining stood by in Sagami Wan to provide fire support for the occupation of Yokosuka Naval Base; but the landings took place without incident.

In October, Twining operated in the waters of Tongjoson Bay, participating in the interdiction of Wonsan harbor where she engaged shore batteries and fired on buildings, road intersections, and railroads.

That night, as she steamed near the channel entrance, an unidentified jet made a quick surprise attack, dropped two bombs, strafed the destroyer, and escaped into the overcast.

Following voyage repairs, she departed Yokosuka, steamed via Midway and Pearl Harbor for the west coast, and arrived at San Diego on 10 March.

[1] In March 1953, she anchored in Buckner Bay before moving to Formosa to train personnel of the Chinese Nationalist Navy in gunnery and damage control.

On 8 April, she rendezvoused with Oriskany to provide antisubmarine screening for the carrier and conducted patrols of the North Formosa Strait before returning to Japan in mid-April.

[1] Although the Korean War was at an end, Twining continued to alternate cruises in the Far East with operations on the west coast until June 1963 when she returned to San Diego from exercises with the British, New Zealand, and Australian navies.