USS Wayne E. Meyer (DDG-108) is an Arleigh Burke-class guided missile destroyer in the United States Navy.

[citation needed] Wayne E. Meyer made her maiden deployment as part of the John C. Stennis Carrier Strike Group (CSG) from 29 July 2011 until 27 February 2012.

[citation needed] In January 2017, Wayne E. Meyer, and her sister ship Michael Murphy, were part of Destroyer Squadron 1, and along with Lake Champlain and Carl Vinson formed Carrier Strike Group One (CSG-1), during a deployment to the western Pacific.

In April of that year, CSG-1 cancelled a scheduled port call in Australia, in response to increasing tensions between the United States and North Korea over the latter's nuclear weapons program.

Wayne E. Meyer arrived at Joint Base Pearl Harbor–Hickam on 13 September, and O'Kane got underway for her new homeport of San Diego.