The first USS Wilkes (TB-35) was a Blakely-class torpedo boat in the United States Navy.

Wilkes was laid down on 3 June 1899 at Morris Heights, New York, by the Gas Engine and Power Company and the Charles L. Seabury & Co.; launched on 28 September 1901; sponsored by Miss Harriet E. Rankin; and commissioned at the Norfolk Navy Yard on 18 September 1902, Lt.

There, she remained until the winter of 1906 and 1907 when she briefly returned to full commission for service with the 3rd Torpedo Flotilla.

There, she remained until 23 November 1908 when she was recommissioned and assigned to duty with the Atlantic Torpedo Fleet based at Charleston, South Carolina.

Apparently in commission, in reserve, while at Charleston, Wilkes was decommissioned there on 14 November 1913, and her name was struck from the Navy list on the following day.