The destroyer escort was designated DE-38 on 16 June; named Wyman on the 23rd; and was commissioned at the Puget Sound Navy Yard on 1 September 1943, Lt. Comdr.

Attending the Naval Reserve Midshipman's School at Northwestern University in Chicago, Illinois, Wyman was commissioned as an ensign on 12 June and reported to the USS Oklahoma on 19 July.

During the attack on Pearl Harbor the Oklahoma was hit by four aerial torpedoes and rolled over at her berth; among those trapped within the ship's hull was Wyman.

Detached from this duty on 22 June 1944, Wyman sailed for the Marshall Islands and began anti-submarine warfare (ASW) operations in the American convoy routes between Eniwetok and Saipan.

Joining Task Group (TG) 12.2, based around Hoggatt Bay (CVE-75), Wyman departed Eniwetok on 5 July and headed for the ASW operating area.

Remaining on the scene of the action, Wyman lowered a motor whaleboat to recover oil samples from the water and to fish out debris.

As it was gathering this materiel, Wyman's motor whaler was strafed by two planes from Hoggatt Bay, whose pilots had mistaken the boat for a surfaced submarine.

Oil from the sunken submarine – later identified by a post-war examination of Japanese records as Ro-48 – continued to bubble up in copious quantities into the next day.

She departed from Ulithi on 13 March 1945 and proceeded to the fueling area for TG 50.8 for duty as escort with the Logistics Support Group for the invasion of Okinawa.

The destroyer escort remained with the 5th Fleet until 10 June, continuing her unglamorous but vital role, screening the important convoys bringing men and munitions to the war zone for the drive against the Japanese homeland.

After a stop at Guam, Wyman headed for the United States, proceeding via Pearl Harbor and Eniwetok, and arrived at San Francisco, California, on 15 July.

Having been stripped prior to her decommissioning, the ship's hulk was sold to the National Metal and Steel Company, of Terminal Island, California, on 16 April 1947 for scrapping, a process which was completed by 14 March 1948.