For the next 10 days, the destroyer tender conducted shakedown training in Chesapeake Bay and then put into Norfolk for additional outfitting and some modifications to her below-deck spaces.

She entered the Ulithi anchorage on 3 March, and her crew set again to work repairing the veteran ships of the war in the Pacific.

The destroyer tender arrived in Sasebo on 22 September and began tending ships assigned to the occupation forces in the Far East.

During that 16-year period, she spent most of her time in port at Newport, Rhode Island, though on occasion she did make voyages to the West Indies.

She concluded that assignment when she returned to Newport on 24 July and resumed duty as tender to the Atlantic Fleet destroyers and as flagship for their type commander.

On 1 April 1962, Yosemite's role changed somewhat when the Atlantic Fleet cruisers and destroyers were brought together into a single type command.

Late that fall, during the Cuban Missile Crisis and the American quarantine of the island, Yosemite departed Newport for a time and headed south via Norfolk to Kingston, Jamaica, where she tended the ships engaged in that operation.

On the voyage home, she took on board a badly burned West German seaman from SS Sinclair Venezuela and transported him to the naval hospital at Newport.

On 24 October, Yosemite's home port was changed from Newport, Rhode Island, to Naval Station Mayport, Florida; and the destroyer tender got underway for that city three days later.

Her final deployment was to the Persian Gulf as part of the ongoing Operation Desert Storm campaign, departing Mayport in October, 1991, with stops in Bahrain and the U.A.E., returning in March, 1992.