After fitting out and shakedown, Zane fueled at Port Costa, California, late in June 1921 and sailed northward to the Puget Sound Navy Yard, Bremerton, Washington, for stores.

Returning south to Mare Island once more, Zane joined Destroyer Division 14 at San Francisco, California, on 22 June and departed that port the following day, bound for the Asiatic Station.

Fortunately, the damage was minor; and Zane proceeded on her way, reaching Shanghai two and a half hours later and moored alongside sistership Rathburne (DD-113) at the American buoys.

Zane set sail from Yantai, homeward bound, on 25 August and visited Nagasaki, Japan, on the first leg of her voyage back to the west coast of the United States.

Recommissioned on 25 February 1930, Zane operated actively as a unit of the Battle Force for the next decade, except for one brief period during which time she was attached to Rotating Reserve Squadron 20 in late 1934.

Converted to a high-speed minesweeper at the Pearl Harbor Navy Yard and reclassified as DMS-14 on 19 November 1940, Zane operated primarily in Hawaiian waters on the eve of World War II.

[1] The crew was just finishing breakfast when, at 0757, a signalman on watch topside observed a single plane drop a bomb on the southern end of Ford Island after a long gliding approach from the northward.

L. M. LeHardy, was senior officer afloat in the division and reported: "0800 Observed Japanese plane gliding low over Ford Island, enemy character now positive.

Commencing fire at "any and all planes which passed within a reasonable distance of the nest" Zane began preparations at 0803 for getting underway, as belting and ammunition supply parties turned to.

Zane's position in the nest, however, rendered her incapable of opening fire with her after 4-inch gun: her aim was fouled by Perry (DMS-17), moored outboard.

The enemy aircraft exploded into flames on the way down and crashed on shore near the recently completed deperming station to the loud cheers of all hands topside in Zane.

Subsequently, returning to sea, Zane resumed antisubmarine patrols, carrying them out at a time when submarine sightings (most of them fictitious) proliferated.

The high-speed minesweeper then underwent repairs and alterations at the Mare Island Navy Yard before she returned to Pearl Harbor in early June.

Accordingly, Zane and four of her sisterships (Hopkins (DMS-13), Southard (DMS-10), Hovey (DMS-11) and Trever (DMS-16)) —were to sweep an area extending from the 100 fathom (183 m) curve toward Port Purvis on Florida Island, but split into two groups near Gavutu Island to head simultaneously toward beach "Red," clearing a 1,000 yards (910 m) wide stretch through Lengo Channel toward Indispensable Strait.

Lookouts noted the stacks and mast-tops of three ships almost simultaneously at 21,000 yards (19 km) distant and bearing 250 degrees, steering a slightly converging course.

The three enemy ships (the destroyers Akatsuki, Ikazuchi, and Shiratsuyu) comprised the 1st Attack Unit, dispatched to provide naval gunfire support during the day to Japanese land forces who had hoped to capture Henderson Field.

The respite offered the two high-speed minesweepers proved fatal to the fleet tug and the YP as the Japanese ships sank them summarily before retiring, harried by American planes from Henderson Field.

Zane later escorted a convoy from the New Hebrides to Tulagi and Guadalcanal before being sent to Sydney, Australia, in January 1943 for repairs and a rest for her crew.

On 22 January 1943, the Japanese submarine I-21 (a craft with an impressive record of "kills" since scoring her first on Christmas Eve 1941) torpedoed and disabled the American steamship Peter H. Burnett.

She then transferred, via motor whaleboat, 13 of the men back to their ship; one man had been retained on board Zane under medical treatment for his injuries suffered when the steamer had been torpedoed.

Zane, as part of Task Unit (TU) 61.1.3, towed four landing craft (two LCVP's, one LCV and an LCM) to the objective area.

Bad weather (low ceilings, moderate showers with corresponding poor visibility, shifting and gusty winds, and choppy seas) hampered "Toenails" from the start; but Zane and Talbot reached the Onaiavisi channel entrance at around 0225 on 30 June to begin their task.

After enough temporary patching to permit the ship to leave Guadalcanal under her own power, Zane headed via Espiritu Santo and Pearl Harbor to the Mare Island Navy Yard for permanent repairs and alterations.

Departing Pearl Harbor on 22 January 1944, Zane subsequently took part in Operation Flintlock, the invasion of the Marshall Islands.

She screened transports during the Kwajalein phase of "Flintlock" and subsequently served as "sweep" ship and mine disposal vessel during the invasion and occupation of Eniwetok.

During the landing phases of "Forager", which commenced on 15 June when Vice Admiral Turner's Task Force 52 (the Northern Attack Force) began sending ashore the marines under the command of Lieutenant General H. M. Smith, USMC, Zane laid down buoys and destroyed drifting mines with gunfire, working once more as mine-destruction vessel.

Subsequently, when marines and Army troops under Major General Roy S. Geiger went ashore on Guam on 22 July under the covering gunfire of Rear Admiral Harry W. Hill's task force, Zane worked as an antisubmarine escort vessel, steaming in the vanguard of a reserve transport group, TG 53.19.

Significantly, the Guam operation proved to be the last front-line tour for the veteran high-speed minesweeper; for, after remaining in the Marianas until 8 August, she reported to Commander, Service Squadron (ServRon) 10, at Ulithi, in the Carolines, for duty as a target-towing vessel.

Zane performed target-towing and local escort duties for the remainder of the war, touching in the Palaus, Marianas, Carolines, and Philippines before V-J Day in mid-August 1945 found her at anchor in San Pedro Bay, off Leyte.

Struck from the Navy list on 8 January 1946, the ship was delivered to Luria Brothers and Company, on 22 October 1946; her hulk was scrapped on 3 March 1947.