The U.S. Bancorp Center is a 467-ft (142 m) tall skyscraper in Minneapolis, Minnesota, United States.

It serves as corporate headquarters for US Bancorp (also referred to as US Bank) and Piper Sandler.

It is the second-tallest office building completed in Minnesota since 2000, after the Ameriprise Financial Center, also in Minneapolis.

The building was among those damaged by rioting during the George Floyd protests in Minneapolis–Saint Paul in May 2020.

This article about a building or structure in Minnesota is a stub.