The Series was initially organized in 2004 as a way to focus more attention on American tennis tournaments by getting more of them on domestic television.

[1] Until 2004, most summer North American tournaments were not on television, the exceptions being the prominent ATP Tour Masters 1000 events in Canada and Cincinnati.

In 2023, its final year, the Series was made up of six tournaments: Newport, Atlanta, Washington D.C., Winston-Salem, Cleveland, and the US Open itself.

[9] The $90 million, seven-year sponsorship deal was supposed to last through 2018, but Emirates decided to reallocate its commitment by sponsoring the line-calling technology on ESPN's US Open Series broadcasts.

Due to several considerable prize money increments over the years, Serena Williams and Rafael Nadal surpassed Roger Federer's US Open Series payday record by winning $3.6 million each, and they shared the record for the largest prize money paycheck in tennis history for a single tennis tournament.

Note: From 2006 on, only players who earned points in at least two US Open Series events are eligible for the final (Top 3) standings.