[2] The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout the region.

The building was dedicated in 2014, designed by Stanley Beaman & Sears, and cost $141.5 million to construct.

[8][9] At over 200,000 sq ft[10] and 7 floors, there are 12 operating rooms in this building and a clinical trials wing.

CHP is a leader in liver transplants after establishing the first liver transplant center in the U.S.[13][14] In 2016 efforts from UVA were made to start renovations all of the pediatric and women's floors of the UVA Children's Hospital.

[19] In the wake of the 2020 Coronavirus Pandemic the hospital revised its visitor policy to only allow one parent of each child to stay overnight on the inpatient wards.