The University of Wisconsin System has had a presence in Manitowoc since 1933, when 26 students enrolled in a UW English class offered at the Vocational School located downtown on Clark Street.

The UW–Green Bay, Manitowoc Campus is accredited by the North Central Association of Colleges and Schools.

The 40-acre (16.2 ha) campus is located on the south side of the city near Silver Creek Park and on the shore of Lake Michigan.

[5] The UW–Green Bay, Manitowoc Campus Blue Devils compete in the East Division of the Wisconsin Collegiate Conference.

The program offers intercollegiate athletic opportunities in co-ed golf, as well as men's and women's basketball, tennis, and volleyball.