It is an American College of Surgeons designated Level I adult and pediatric trauma center, one of only two in Wisconsin.

[6] UW Health serves over 950,000 patients per year, and employs over 24,000 employees across seven hospitals, 4 medical centers, 90+ clinics/specialty clinics, 3 urgent cares, 4 behavioral health centers and 1 community service center., making it the second-largest employer in Madison (after UW–Madison) and in Wisconsin.

In 1979,[9] it moved to a new facility at 600 Highland Avenue, Madison, Wisconsin, and the original building was converted for use by the university as classrooms.

The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[15] throughout Wisconsin and surrounding states.

American Family Children's Hospital features the only pediatric Level 1 Trauma Center in the region, and 1 of 2 in the state.

As of 2023, UW Health employed approximately 24,000+ employees throughout all of its hospitals, clinics and supportive centers.