The single performed well internationally, peaking atop the radio charts of the Czech Republic and Hungary and reaching the top 10 in over 10 other countries.

Pink wrote the song with Max Martin, Luke Gottwald, and Rami, with a lyrical focus on mocking the men who would flirt with her in clubs.

[12] According to Tom Carraba, Zomba Label Group general manager and executive vice president of sales and marketing, the "patience" of radio stations, the "great" music video for the single and Pink's participation in Justin Timberlake's FutureSex/LoveShow tour was responsible for the increase in popularity of "U + Ur Hand", which consequently led to renewed interest in the album.

[14] British newspaper The Guardian wrote, "the pithy put-downs of ["U + Ur Hand"] make bearable the sudden shift from classy beats to lumpen power pop".

[15] Entertainment Weekly told that "including one that's destined to be an instant word-of-mouth smash: the irresistibly rude U + Ur Hand, in which Pink tells a drunken club suitor just whom he'll be having sex with later (the title provides the answer).

U + Ur Hand uses a Joan Jett stomp to give a singles-bar Lothario a brusque brushoff, warning, I'm not here for your entertainment/ You don't wanna mess with me tonight.

[17] Pink shot the music videos for "U + Ur Hand" and "Stupid Girls" simultaneously, before the decision was made to release the latter as the first single from I'm Not Dead.

[1][18] The outfit that Pink was wearing in the bedroom scene consisted of pieces of black lace that was imported from France and cost US$300 per yard of the fabric.

[18] The music video for "U + Ur Hand" premiered on Canada's MuchMusic network on July 18, 2006, and was released in Europe at the end of August.

The video features Pink posing as several of New Zealand artist Martin Emond's characters, including "Baby Red Knuckles", "Rocker Bikergirl" and "Hard Candy".