The film tells the story of Ajay (Devgn), who meets barmaid Piya (Kajol) on a cruise with his friends (Sumeet Raghavan, Divya Dutta, Karan Khanna, and Isha Sharvani).

A younger Ajay is on a cruise with four friends: Nikhil and Reena (an unhappily-married couple) and Vicky and Natasha, who are happily unmarried.

The cast is listed below:[3][4] In May 2007, the entertainment portal Bollywood Hungama reported that Ajay Devgn would make his directorial debut in a project which was later entitled U Me Aur Hum.

The screenplay was written by Robin Bhatt, Sutanu Gupta, and Akash Khurana, and Ashwni Dhir polished the dialogue.

[6] It was their seventh collaboration, following the action films Hulchul (1995), Gundaraj (1995), and Raju Chacha (2000), the romantic comedies Ishq (1997) and Pyaar To Hona Hi Tha (1998), and the drama Dil Kya Kare (1999).

[11] Devgn believed her involvement in the film made his work as director "much easier", describing the opportunity to collaborate once again with the actress.

[12] Principal photography was completed by Aseem Bajaj and began at the Manoranjan Studio in Andheri, with Sameer Chandra as the production designer.

[16] In a Bollywood Hungama review, Joginder Tuteja wrote that the singers had made their best effort and said about the title song: "It's a beautiful track that is as melodious as it gets and flows in a direction ..."[17] Meghna Menon of Hindustan Times wrote that Bhardwaj had "once again hit the jackpot" with the film's soundtrack and commending Dhiman's unconventional lyrics.

[21] A special screening was given by sitar virtuoso and composer Ravi Shankar for critic-turned-politician L. K. Advani on 6 April 2008 in the Films Division of India auditorium in Delhi, also attended by a cast member and Sushma Swaraj.

[22] Distributed by Eros International,[5] U Me Aur Hum was released theatrically on 11 April 2008 with Jaideep Sen's comedy thriller Krazzy 4.

[26] Taran Adarsh of Bollywood Hungama wrote about the actors, "U Me Aur Hum is like a medal that glimmers on Ajay Devgan's body of work.

[38] A Rediff.com reviewer gave U Me Aur Hum 3+1⁄2 stars, saying that Devgn had delivered a "fantastic" work by telling a "powerful" story without "resorting to that most traditional and painful of Bollywood cop-out methods, the flash-cuts".

Ajay Devgan oozes sincerity as the conflicted husband, but it’s Kajol who is really the emotional anchor of the film, dazzling you with her spontaneity, pumping life and blood into her character, making Piya a portrait of internalized pain, something even the script fails to do.

"[40] For Screen, Rajiv Vijayakar called Devgn and Kajol's performances "stupendous" and "terrific"; the film's direction and screenplay, however, were its "undoing".

In his three-star review, Vijayakar said that the supporting cast (particularly Sumeet Raghavan and Divya Dutta) were "great" and "admirably restrained".

He praised the latter ("sipping her coffee, her luminous eyes exuding rare brilliance"), and felt that Devgn's performance was overshadowed by hers.

"[44] The Economic Times' Gaurav Malini, who gave U Me Aur Hum three stars, commended both actors for playing to "perfection" and the film "raises much above the candyfloss or campus romance regularly churned out" in Bollywood.

[45] Namrata Joshi of Outlook was ambivalent about the acting, criticising Kajol for being "terribly contained" and Devgn's "dreadful" effort to play a rakish, cool man, and said that only Raghavan and Dutta remained as a "good performer" in the film.

[46] In the Hindustan Times, Khalid Mohamed wrote: "For its tear-drawing emotional content, a splendid performance by Kajol and Devgan’s fluid makeover from an actor of steel to a director of tenderness, you ultimately take U Me Aur Hum home with you.

She described the film as "Devgn's confident debut", adding, "... hopefully next time round, he'll choose to appease the audience’s mind as well, and not just aim for the heart.