[3] The district lies in the southeastern part of the Valdai Hills and is split between the drainage basins of the Baltic and Caspian Seas.

The rivers in the western part of the district drain into the Msta, a major tributary of Lake Ilmen, which belongs to the basin of the Neva and thus of the Baltic Sea.

The area of the district was originally populated by the Finnic peoples, in the 11th century, Slavs started to arrive.

Udomelsky District, with the administrative center in the railway station of Udomlya, was established within Tver Okrug of Moscow Oblast.

On June 1, 1936 Brusovsky District with the administrative center in the settlement of Brusovo was established as a part of Kalinin Oblast.

[10] The main industrial enterprise in the district is the Kalinin Nuclear Power Plant, located in Udomlya.

[13] The railway connecting Rybinsk and Bologoye via Bezhetsk crosses the district from east to west.

The federal monuments are the tomb of artist Alexey Venetsianov in the selo of Venetsianovo, as well as three archeological sites.

[15] The former Datcha Chayka on the shores of Lake Udomlya, which belonged to artist Vitold Byalynitsky-Birulya, is also open as a museum.