Uedem is a municipality in the district of Cleves, in North Rhine-Westphalia, Germany.

The history of Uedem goes back to the 5th century when Frankish nobleman Udo started a settlement in the area.

In November 1614, the Treaty of Xanten was signed in Cleves, dividing some of the territory around Uedem.

After the Nazi takeover in 1933, Uedem fell under the administrative control of Gau Essen.

Bombing during World War 2 destroyed parts of Uedem, but the city has since recovered.