In Langwedel it formed a junction with the line to Wunstorf, that was owned 50/50 by Bremen and Hanover and operated by the Royal Hanoverian State Railways.

Profits on the Langwedel–Uelzen section were initially split in a 2:1 ratio between the Magdeburg-Halberstadt Railway Company (MHE) and Bremen, until operations were taken over by Prussia.

At the end of the 1930s there was a collision between a bus and Adolf Hitler's train at the level crossing near Walle which resulted in several fatalities.

[2] In February 1945 a refugee train was destroyed during an air raid near the villages of Scharnhorst and Walle resulting in a high death toll.

Even after the fall of the Berlin Wall the non-electrified line was of little importance within the Deutsche Bahn network and has had very little in the way of modernisation measures.

The Federal Railway Office (EBA) had set Deutsche Bahn a deadline after when it threatened to ban operations between Langwedel and Soltau.

Up to December 2008 passenger services consisted of Regionalbahn trains run by DB Regio as part of the Uelzen-Bremen route, not all of which were operated to a fixed-interval system.

Following the changeover of timetables in December 2008, RegionalBahn trains now only run between Uelzen and Langwedel; passengers have to change for Bremen.

Since 2024 some gravel hauling trains with EGP Eisenbahn Gesellschaft Potsdam diesels and MKB Mindener Kreis-Bahn Dual-Mode engines are spotted.

Nevertheless, there are regular discussions about electrifying and upgrading the line for goods traffic, especially as a junction to the JadeWeserPort container port at Wilhelmshaven.

There is also an intent to double the line between Tadel (between the old stations of Jeddingen and Bendingbostel) and Langwedel as part of the new wye section (Y-Trasse) on the Hanover–Bremen route for the high speed trains; but construction has been delayed several times and its future is uncertain.