Uesugi Zenshū (上杉 禅秀, d. 1417), also known as Uesugi Ujinori, was the chief advisor to Ashikaga Mochiuji, an enemy of the Ashikaga shogunate in feudal Japan.
When he was rebuked by Mochiuji in 1415, and forced to resign, Zenshū organized a rebellion.
Zenshū received aid for his rebellion from nearly half the daimyōs in the northern and eastern provinces, and took Kamakura.
They fled to Kamakura's Tsurugaoka Hachimangū, where Zenshū committed seppuku.
Anger towards Mochiuji and his office only continued to grow, until the bakufu took action to stop him in 1423.