Situated in the Blackdown Hills on the B3440, close to the M5 motorway and the Bristol–Exeter railway line, near Cullompton, Uffculme is on the upper reaches of the River Culm.

[1] It is surrounded, clockwise from the north, by the parishes of Culmstock, Hemyock, Sheldon, Kentisbeare, Cullompton, Willand, Halberton and Burlescombe.

Uffculme is of particular interest to local historians because the wills and inventories for Uffculme have survived due to the parish being a peculiar of the Bishop of Salisbury, and hence they were not among the Devon probate records that were destroyed by fire in Exeter following a bombing raid during the Baedeker Blitz of World War II.

[9] The large Elizabethan manor house of Bradfield, with Victorian extension, the historic home of the Walrond family, is situated within the parish of Uffculme.

Coldharbour Mill remains a popular tourist attraction, with its working wool museum exhibits, as do the scenic old railway and riverside walks.