Sir Ugo Pasquale Mifsud (12 September 1889 – 11 February 1942) was a Maltese politician, the 3rd Prime Minister of Malta under British home rule, and the first to serve a full term in power.

[2] When Sir Filippo Sciberras rallied a Maltese legislative assembly to draft a liberal Constitution to submit to the British colonial government, Mifsud was elected secretary of the sitting.

Following the merger of the UPM with Enrico Mizzi's PDN, in 1926 Mifsud became co-leader of the newly formed Partito Nazionalista (PN).

[2] During this term, in 1932, he travelled with a delegation to London to submit a memorandum to Sir Philip Cunliffe-Lister, Secretary of State for the Colonies, with a formal request for Malta to be placed under the Dominions Office as an independent member of the Commonwealth.

One of three [Nationalist Party (Malta)] members of the Council of Government members during the Second World War, he vehemently opposed the internment and illegal deportation in Uganda of his party leader and fellow colleague in the Council, Dr Enrico Mizzi, and other Maltese politicians without due process of law on suspicion of anti-British and pro-Italian activities.