Uherský Ostroh consists of three municipal parts (in brackets population according to the 2021 census):[2] The name literally means "Hungarian promontory".

It included a water fortress near a ford across the Morava, founded here by Ottokar II of Bohemia.

After the Battle of White Mountain in 1620, the properties of lords of Kunovice were confiscated from them, and Uherský Ostroh was acquired by the Liechtenstein family, who owned it for almost 300 years.

Uherský Ostroh suffered from frequent floods and raids by Turks and Hungarians, however it remained a small agricultural and craft town.

The I/71 road splits from it and connects Uherský Ostrov with the Czech-Slovak border in Velká nad Veličkou.

Annual cultural events in the town include ceremonial opening of the tourist season, theatrical mini-festival, European Heritage Days celebrations, and hody.