Their entrant was Olena Usenko with the song "Vazhil", who won the national selection organised by the Ukrainian broadcaster Suspilne.

[5] In the 2020 contest, Oleksandr Balabanov represented the country in Warsaw, Poland with the song the "Vidkryvai (Open Up)", placing 7th out of 12 entries with 106 points.

[7] Unlike the previous two years, where the national selections took place either online or behind closed doors, the final was the first one since 2017 to be televised live.

[13] Darya Rebrova, Daryna Kryvenko, Mariya Tkachuk, Olena Usenko and RREALINA (stage name of Anzhelina McFarlane) had all competed in previous Ukrainian national finals.

On 23 October 2021, it was announced by the broadcaster that the song "Angel of Light" performed by RREALINA had been disqualified due to not obtaining the consent of the composer to participate in the final.

[17] The jury panel that was responsible for 5/6 of the final result consisted of: Alyosha (Ukrainian representative at the Eurovision Song Contest 2010), Ihor Kondratiuk [uk] (TV host and record producer), Liuba Morozova (musicologist), Ihor Panasov (editor-in-chief of Karabas Live) and Oleksandr Balabanov (Ukrainian representative at the Junior Eurovision Song Contest 2020).