The American elm cultivar Ulmus americana 'Lewis & Clark' (trade name Prairie Expedition) is a development from the North Dakota State University (NDSU) Research Foundation breeding programme, released in 2004 to commemorate the 200th anniversary of the eponymous expedition.

[3] Prairie Expedition was introduced to the UK in 2008 by Hampshire & Isle of Wight Branch, Butterfly Conservation, as part of an assessment of DED-resistant cultivars as potential hosts of the endangered White-letter Hairstreak.

Possession of an innate resistance to Dutch elm disease was suggested after inoculation with the causal fungus at the NDSU,[7] however replication of the tests is considered too limited to be conclusive.

No other specific information available, but the species as a whole is highly susceptible to Elm Yellows; it is also moderately preferred for feeding and reproduction by the adult Elm Leaf Beetle Xanthogaleruca luteola,[8] and highly preferred for feeding by the Japanese Beetle Popillia japonica [9][10] in the United States.

[11][10] Prairie Expedition has been included in the National Elm Trial coordinated by Colorado State University.