It features production from Gregg Pagani, The Underdogs, Bigg D, T-Pain and Los da Mystro.

It features guest appearances from Snoop Dogg, Jamie Foxx and T-Pain.

It debuted and peaked at number two on the US Billboard 200 with first week sales of 58,000 copies.

At the 52nd Grammy Awards, Uncle Charlie was nominated for Best R&B Album, while the single "There Goes My Baby" was nominated for Best Male R&B Vocal Performance.

AllMusic editor David Jeffries found that Uncle Charlie "follows the formula of the former Gap Band vocalist's previous release, Charlie, Last Name Wilson [...] The big difference here is that Charlie has taken the duties away from his last executive producer, R. Kelly, but with the Underdogs, T-Pain, and frequent Babyface collaborator Greg Pagani behind the boards, he's got all the help he needs.