[6] After graduating from Miami Beach Senior High School in 1979, Campbell was asked by his mother to leave the house every weekday from 8:30am to 4:30pm regardless of his employment status.

In 1983, he also enrolled in an eight-week study course at Miami public radio station WDNA, where he learned basic audio editing and production techniques.

In 1984, Campbell took notice of a single from California named "Revelation" by 2 Live Crew, which consisted of two rappers (Fresh Kid Ice and Amazing V) and a DJ (Mr. Mixx).

Their third album As Nasty as They Wanna Be (1989) became the group's largest seller, being certified platinum by the Recording Industry Association of America.

In 1993, Campbell threatened to go public with various alleged violations by the university's athletic department and its football program if Ryan Collins, a black player on the team, wasn't named starting quarterback that season.

[15] The eponymous title single is a reference to the decision in a court case that the group's album As Nasty as They Wanna Be was obscene.

[16] Displeased over the decision of Florida Governor Bob Martinez who, on being asked to examine the album, decided it was obscene and recommended local law enforcement take action against it and over the subsequent action of Broward County, Florida, sheriff Nick Navarro, who arrested local record-store owners on obscenity charges for selling the group's albums and the subsequent arrest of members of the group on obscenity charges, the group included the song "Fuck Martinez", which also includes multiple repetitions of the phrase "fuck Navarro".

The group found two other men with the same names, and had them sign releases, as they thought that this action would make it impossible for Martinez or Navarro to sue them.

It was the album that spawned the hit single "I Wanna Rock" (better known more prominently as "Doo-Doo Brown"), which became Campbell's signature song.

[20] One of The 2 Live Crew’s songs, which used a parody of Roy Orbison's "Oh, Pretty Woman", was the subject of a 1993-1994 lawsuit, Campbell v. Acuff-Rose Music, Inc., which was argued in front of the U.S. Supreme Court.

[21] In 1994, he reunited with Fresh Kid Ice, and a local rapper named Verb made an album under the banner The New 2 Live Crew.

Uncle Luke was released on May 14, 1996, on Luther Campbell Music and was mainly produced by Darren "DJ Spin" Rudnick, and Rod XL, with additional production by Frankie Cutlass, Ice Cube and Doug E. Fresh.

It was released on November 11, 1997, on the Island Black Music label in collaboration with Luke Records and featured production from Campbell, Rod XL, Lil' Jon and Louis "Ugly" Howard.

The comedy/drama film stars Bernie Mac, Monica Calhoun, Jamie Foxx, John Amos, A. J. Johnson, Alex Thomas, Charlie Murphy, Terrence Howard, Faizon Love and LisaRaye.

[25] The first singles serviced to radio were "Holla at Cha Homeboy", featuring Pitbull & Petey Pablo, and the reggaeton-leaning "Pop That" by Plan B and Rey Chester Secretweapon.

[26] That same year, Campbell appeared in Grand Theft Auto: Vice City Stories as DJ Luke for the hip-hop station Fresh 105 FM.

In December 2007, Campbell launched The Luke Entertainment Group and took the company public trading under the symbol LKEN on Pink Sheets.

Campbell was interviewed about his involvement with the University of Miami football program for the documentary The U, which premiered December 12, 2009, as part of ESPN's 30 for 30 series.

In 2010, he briefly reunited with Fresh Kid Ice, Brother Marquis, and Mr. Mixx as the 2 Live Crew were honorees winners at the 2010 VH1 Hip-Hop Honors: The Dirty South Edition.

[29] On February 2, 2011, Campbell announced his intention to run for mayor of Miami-Dade County on a platform that includes making housing projects safer, transparency in local government, and taxing strippers.

[35] Campbell's column, called "Luke's Gospel",[36] provides "a forum for his crazy-ass views on current events," which include politics, sports and entertainment.