"Reno" Tony Reagan (Scott Brady) was a low-level member of the Chicago syndicate; he was run out of town back then for being involved with the kingpin Big Jim's niece.

Seven years later, Reagan has been vacationing in Reno, at a lodge in which he intends to invest with the father of an old army buddy.

On his way home to Chicago to propose to his girl, Reagan shares the flight with a schoolteacher, Ann McKnight (Peggy Dow), someone he met at a Reno casino and helped win at the gambling table.

On the run from both the police and the unknown murderers, Reagan enlists the help of McKnight and an old buddy, Charles Reckling (Bruce Bennett), a detective.

They discover the truth: Morgan is also engaged to Sally Lee, and together they are responsible for murdering her uncle and framing Reagan.