Unexplained infertility

Also, polymorphisms in folate pathway genes could be one reason for fertility complications in some women with unexplained infertility.

In women who have not had previous treatment, ovarian stimulation combined with IUI achieves approximately the same live birth rate as IVF.

[8] On the other hand, in women who have had previous unsuccessful treatment, IVF achieves a live birth rate approximately 2–3 times greater than ovarian stimulation combined with IUI.

[10] Rather, it is recommended that in vitro fertilization should be offered to women with unexplained infertility when they have not conceived after two years of regular unprotected sexual intercourse.

[8] Prognosis in unexplained infertility depends on many factors, but can roughly be estimated by e.g. the Hunault model, which takes into account female age, duration of infertility/subfertility, infertility/subfertility being primary or secondary, percentage of motile sperm and being referred by a general practitioner or gynecologist.