It was built in the Richardsonian Romanesque style in 1889–1890 and added to the National Register of Historic Places in 1975.

Regular passenger train service no longer exists, though there are proposals such as Front Range Passenger Rail, which would provide service to Denver and Colorado Springs.

[1] In addition, the depot has been proposed to operate on Amtrak's Southwest Chief.

[2] Presidents Theodore Roosevelt and Woodrow Wilson arrived at the depot, as did vice-presidential candidate Joe Biden and presidential candidate John Kerry.

Media related to Pueblo Union Depot at Wikimedia Commons