In addition to the Rock Island and Cotton Belt, the station also served branchline trains of the Missouri Pacific.

[citation needed] Named passenger trains which stopped at Brinkley Union Station include: The station and nearby railroad hotel are listed on the National Register of Historic Places as Lick Skillet Railroad Work Station Historic District and Rusher Hotel.

After sitting abandoned for a number of years, Brinkley Union Station has now been restored and is operated as the Central Delta Depot Museum, a local history museum run by the Central Delta Historical Society.

Exhibits focus on the natural, social, agricultural, and cultural history of the Arkansas Delta region.

The grounds include a train depot originally located in Monroe, Arkansas; a sharecropper’s house; and a Southern Pacific Railroad caboose.