It has a 1+1⁄2-story, Flemish bond brick main block covered by a medium-pitched hip roof sheathed in slate, with single-story wings.

From the 1920s to the 1950s, the PRR ran several passenger trains a day, including the Del-Mar-Va Express, through the station, north–south from Philadelphia to Cape Charles, Virginia.

The building has characteristics of the Colonial Revival style and was the most elaborate passenger facility to survive on the Eastern Shore of Maryland.

[4] Union Station was listed on the National Register of Historic Places in 2007.

[1] Until the mid-1950s the Pennsylvania Railroad ran the day train, the Del-Mar-Va Express from Philadelphia in the north, through Salisbury to Cape Charles, Virginia to the southern end of the Delmarva Peninsula.