The front facade features a limestone portico supported by paired heroic columns with stylized Corinthian order capitals.

In 2018 the city hired Walter Robbs Callahan & Pierce Architects and New Atlantic Contracting to restore the station, and it had a grand reopening on September 7, 2019.

Union Station currently serves as a secondary bus hub for the Winston-Salem Transit Authority, after the Clark Campbell Transportation Center.

On December 8, 2023, the Federal Railroad Administration included an Amtrak route connecting Winston-Salem to Raleigh into the Corridor Identification and Development Program.

The proposed route would include intermediate stops at Greensboro, Burlington, Durham, and Cary, complementing the existing state-supported Piedmont and Carolinian services.