Its main campus is located in Southern Brazil, in the city of São Leopoldo, state of Rio Grande do Sul (Sinos River valley region).

Unisinos' campus has a technological park, TECNOSINOS, which consists of 75 companies from 10 different countries, including the South Korean HT Micron and the German SAP Labs Latin America.

TECNOSINOS was selected as the best technological park in Brazil by ANPROTEC (National Association of Entities Promoting Innovative ventures) in 2010 and 2014.

A century after its beginning, on July 31, 1969, the feast of Saint Ignatius of Loyola, Unisinos received official recognition as a university.

It aims to recreate a part of the history of Rio Grande do Sul, told through more than 8000 objects brought from the Geopark of Paleorrota by professionals in the fields of geology and biology.