This is a list of ambassadors of the United States to Cambodia.

The United States had appointed its first envoy to Cambodia, Donald R. Heath, in 1950.

Heath was a non-resident minister who was commissioned to Cambodia, Laos, and Vietnam, while resident in Saigon.

Diplomatic relations between Cambodia and the United States were broken twice: The first time between 1965 and 1969, and the second time in 1975 just before the Pol Pot regime gained control of the country.

The U.S. Embassy in Cambodia is located in Phnom Penh.