Since 1840, the United States has had diplomatic representation in the Italian Republic and its predecessor nations, the Kingdom of Sardinia and then the Kingdom of Italy, with a break in relations from 1941 to 1944 while Italy and the U.S. were at war during World War II.

The U.S. Mission to Italy is headed by the Embassy of the United States in Rome, and also includes six consular offices.

[2][3] Listed below are the head U.S. diplomatic agents in Italy, their diplomatic rank, and the effective start and end of their service in Italy.

Diplomatic relations were severed and the U.S. Embassy in Rome was closed on December 11, 1941, after Italy declared war on the United States.

Ambassador Alexander C. Kirk reopened the U.S. Embassy in Rome when he presented his credentials on January 8, 1945.