Liberia, as a nation, had its beginnings in 1821 when groups of free blacks from the United States emigrated from the U.S. and began establishing colonies on the coast under the direction of the American Colonization Society.

Between 1821 and 1847, by a combination of purchase and conquest, American Societies developed the colonies under the name "Liberia", dominating the native inhabitants of the area.

Because it was already established as a nation, Liberia avoided becoming a European colony during the great age of European colonies in Africa during the latter half of the 19th century.

The status of the commissioner was later upgraded to Minister, and finally to full ambassador in 1949.

Relations between the United States and Liberia have been continuous since that time.