The United States ambassador to Saint Kitts and Nevis (or, prior to August 3, 1988, to Saint Christopher and Nevis) is the official representative of the government of the United States to the government of Saint Kitts and Nevis.

The United States established diplomatic relations with Saint Christopher and Nevis on September 20, 1983, but no U.S. mission has ever been established at Basseterre.

After June 25, 1988, all relations were handled by the Embassy at St. John's, Antigua and Barbuda.

Ambassador to Saint Kitts and Nevis is resident.

The following is a list of U.S. ambassadors, or other chiefs of mission, to Saint Kitts and Nevis.