The history of ambassadors of the United States to Zambia began in 1964.

On October 24, 1964, Northern Rhodesia gained full independence as the Republic of Zambia.

The United States immediately recognized the new nation and moved to establish diplomatic relations.

The United States embassy in Zambia is located in Lusaka.

The U.S. ambassador to Zambia serves concurrently as the U.S. representative to the Common Market for Eastern and Southern Africa (COMESA).