is the United States district court that serves the eastern 44 counties in North Carolina.

The eastern division is headquartered in Greenville and handles cases from Beaufort, Carteret, Craven, Edgecombe, Greene, Halifax, Hyde, Jones, Lenoir, Martin, Pamlico, Nash and Pitt counties.

The southern division is based in Wilmington and serves the counties of: Bladen, Brunswick, Columbus, Duplin, New Hanover, Onslow, Pender, Robeson, and Sampson.

The western covers: Cumberland, Franklin, Granville, Harnett, Johnston, Vance, Wake, Warren, Wayne, and Wilson counties.

The northern division presides over cases from: Bertie, Camden, Chowan, Currituck, Dare, Gates, Hertford, Northampton, Pasquotank, Perquimans, Tyrrell and Washington counties.

[2][3] In both instances, these districts, unlike those with geographic designations that existed in other states, were titled by the names of the cities in which the courts sat.

[4] As of January 12, 2025[update]: Chief judges have administrative responsibilities with respect to their district court.