is a United States district court with jurisdiction over 24 counties in the center of North Carolina.

The U.S. District Court for the Middle District of North Carolina has jurisdiction over 24 counties: Alamance, Cabarrus, Caswell, Chatham, Davidson, Davie, Durham (excluding that portion of Durham County encompassing the Federal Correctional Institution, Butner, North Carolina), Forsyth, Guilford, Hoke, Lee, Montgomery, Moore, Orange, Person, Randolph, Richmond, Rockingham, Rowan, Scotland, Stanly, Stokes, Surry, and Yadkin.

[1] The district's jurisdiction was modified in 2021 to transfer the portions of four counties (Hoke, Moore, Richmond, and Scotland) containing Fort Bragg Military Reservation and Camp Mackall to the Eastern District of North Carolina.

[3][4] In both instances, these districts, unlike those with geographic designations that existed in other states, were titled by the names of the cities in which the courts sat.

On June 4, 1872, North Carolina was re-divided into two Districts, Eastern and Western, by 17 Stat.

The chief judge serves for a term of seven years, or until age 70, whichever occurs first.