Russ Carnahan Democratic Russ Carnahan Democratic In this fairly liberal district based in the southern portion of St. Louis and previously represented by House Minority Leader Dick Gephardt, Democratic Congressman Russ Carnahan easily defeated Republican Chris Sander, Libertarian Kevin Babcock, and Constitution Party candidate Cindy Redburn to win a third term.

Ike Skelton Democratic Ike Skelton Democratic Long-serving incumbent Democratic Congressman Ike Skelton, the Chairman of the House Armed Services Committee, easily defeated Republican nominee Jeff Parnell in this conservative, west-central Missouri district to win a seventeenth term.

By contrast, in the simultaneous 2008 presidential election the district gave 61 percent of its vote to Republican nominee John McCain and 38 percent to Democratic nominee Barack Obama, making this the only Missouri district with opposite results in the two elections.

Barnes' inability to capitalize on the strong Democratic wave sweeping the country ultimately left her defeated in this normally conservative district based in northwest Missouri.

Jo Ann Emerson Republican Jo Ann Emerson Republican In this staunchly conservative district based in southeast Missouri, incumbent Republican Congresswoman Jo Ann Emerson had no difficulty in dispatching Democrat Joe Allen, Libertarian Branden McCullough, and Constitution candidate Richard Smith to win another term in office.