The winning team in the tournament represents the United States at that year's World Mixed Doubles Curling Championship.

[1] The 2021 Championship was originally planned to be held February 28 to March 6, 2021 at Great Park Ice & FivePoint Arena in Irvine, California and also be the Mixed Doubles Olympic Trials for the 2022 Winter Olympics.

[2] In December, 2020, the USCA announced that all remaining 2020–21 events would be either cancelled or postponed until late spring 2021.

This postponement delayed the Mixed Doubles Championship until after the 2021 World Mixed Doubles Championship and so the 2020 champions, Tabitha Peterson and Joe Polo, were selected to represent the United States.

[3] On March 29, 2021 it was announced that the 2021 Mixed Doubles Championship will be held in conjunction with the Women's Nationals and Men's Nationals in a bio-secure bubble at Wausau Curling Club in Wausau, Wisconsin in May, 2021.